the nose that has been present for about six months.
O/E: The examination shows a healthy, outgoing woman with type I skin. There is a solitary 3 mm in diameter dome-shaped papule with a central keratin on the bulb of the nose. The remainder of the cutaneous examination is unremarkable.
Clinical and Dermatoscopic Images:
Preoperative diagnosis: This has the appearance of keratoacanthoma, squamous cell carcinoma, or hypertrophic actinic keratosis.
PLAN: The lesion was shave excised. The base was lightly electrodesiccated and curetted and a
specimen was submitted for pathology.
Pathology: Assistant Professor Hye Jin Chung, MD from Boston University Skin Pathology kindly provided the photomicrographs.
At x4: parakeratosis, papillomatosis and a lobular proliferation of pale cells
At x10: peripheral palisading with focal eosinophilic hyaline basement membrane
Diagnosis: Solitary Tricholemmoma
Daignosis: Solitary tricholemmoma. Tricholemmomas can be a marker for Cowden's disease. However, I don't feel that a solitary tricholemmoma is a red flag in a 39 yo woman. I asked the patient about a personal or family history of cancer and there was no history of thyroid, lung or colon.
This case is presented because there are few to no accessible cases of solitary tricholemmoma online and no dermatoscopic images that I could fine..
Reference:
Spiegel JH, Khodai N. Tricholemmoma of the nose. Am J
Otolaryngol. 2006 Nov-Dec;27(6):430-2.
Abstract
OBJECTIVES: The objectives of this case report are to (1)
identify clinical presentations of tricholemmoma, (2) discuss the
characteristics of Cowden syndrome and the relationship between this syndrome
and tricholemmoma, and (3) differentiate tricholemmoma from other superficial
cutaneous tumors such as basal cell carcinoma and granulomas.
RESULTS:
Tricholemmoma was first described as a cutaneous neoplasm in
1962. It is associated with the Cowden syndrome and can be misdiagnosed as a
more aggressive cutaneous malignancy. We report an unusual case of
tricholemmoma presenting as a nasal mass.
CONCLUSIONS: Tricholemmoma is described as having a
predilection for the head and neck, yet little information has been published
about this disorder within the Otolaryngology literature. Otolaryngologist-head
and neck surgeons must be familiar with this neoplasm because it can be
frequently misdiagnosed as an aggressive cutaneous malignancy and hence can be
incorrectly treated. We describe the presentation and diagnosis of
tricholemmoma, describe the frequent association of this neoplasm with Cowden
syndrome, and report an unusual presentation of tricholemmoma as an intranasal
mass.
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