53-year-old man who was seen for a general skin
examination. He has Crohn's disease and
has been on 6-MP for the past 8-10 years.
His gastroenterologist said because of this he should have a skin
examination.
O/E: The patient has
type II skin. He has a 6 mm in diameter pink
papule on the calf of the left leg. Dermoscopically,
this lesion has a dotted vascular pattern.
IMPRESSION: Lesion
left calf. Etiology unclear.
Plan: Excisional biopsy was obtained.
Reference:
Inflammatory Bowel Disease Treatment and Non-melanoma Skin Cancer: Jacqueline F De Luca, MD, Yun Sun Lee, MD, and Douglas Johnson, MD, Hawaii J Med Public Health. 2012.7:324–325.
Plan: Excisional biopsy was obtained.
Reference:
Inflammatory Bowel Disease Treatment and Non-melanoma Skin Cancer: Jacqueline F De Luca, MD, Yun Sun Lee, MD, and Douglas Johnson, MD, Hawaii J Med Public Health. 2012.7:324–325.
Abstract:Immunosuppressant medications for Inflammatory
Bowel Disease can help with both symptoms and disease progression. However,
like immunosuppressants used in transplant patients, they are now suspect of
contributing to nonmelenoma skin cancer (NMSC). Presented is a case of a
57-year-old Jewish man with Crohn's Disease who was diagnosed with a total of
84 NMSCs. We hope to elucidate the risk of immunosuppressants, particularly the
thiopurines, on the development of NMSC.
