Wednesday, August 19, 2020

Lymphangioma Circumscriptum

The patient is an active 10-year-old boy who was seen today for evaluation of a vascular anomaly on his right knee that has been present since birth.  It was biopsied in March 2017 and the histologic diagnosis was "lymphatic malformation consistent with a lymphangioma." 

Occasionally, his knee will swell and he will get some bleeding spots.  He is learning boxing and that can precipitate swelling. He never has pain.  Has not had any infection.  I referred him to a pediatric dermatologist 3 years ago but they were out of network and he never went. 

The lesion measures 7 cm in diameter on the right knee.  There are areas of dark purplish pigmentation in confluent vesicles. 

Clinical photos:


Pathology: There were multiple dilated irregular thin walled vessels lined by a single layer of bland endothelial cells.

IMPRESSION:  Lymphangioma circumscriptum.  I expect there is a deep component.  The patient has no lymphedema.  Note: The new terminology for this is "Microcystic Lymphatic Malformation (Ref 4.)

Question:  Should this tumor be evaluated and if so how?  Would any therapy be better than active surveillance?

 References:

1. Lymphangioma

Alyssa Miceli, Kristen M. Stewart  In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan. 2020 Aug 12. Free Full Text.

Excerpt:

Lymphangiomas are uncommon, benign malformations of the lymphatic system that can occur anywhere on the skin and mucous membranes. Lymphangiomas can be categorized as deep or superficial based on the depth and size of the abnormal lymphatic vessels or as congenital or acquired. The deep forms of lymphangioma include two specific well defined congenital entities: cavernous lymphangiomas and cystic hygromas. Superficial forms of lymphangioma include lymphangioma circumscriptum and acquired lymphangioma, which is also referred to in the literature as lymphangiectasia. Although both entities share similar clinical and histologic features, the term lymphangioma circumscriptum infers lymphatic channel dilation due to a congenital malformation of the lymphatic system. Whereas, the term lymphangiectasia, or acquired lymphangioma, denotes dilated lymphatic channels of previously normal lymphatics that have become obstructed by an external cause.

2. The Possible Role of Color Doppler and Pulse Wave Doppler Ultrasound in the Diagnosis of Cutaneous Lymphangioma Circumscriptum. Yang Sun, et. al. J Craniofac Surg. Jan/Feb 2020
Abstract
: Cutaneous lymphangioma circumscriptum (CLC) is an uncommon congenital lymphatic malformation. Its dermoscopic features have been reported, however, if blood has infiltrated the lacunas, a pink hue overwhelms the lacunar structures, rendering dermoscopic features indistinguishable. In addition, dermoscopy cannot assess the subcutaneous extent of the lesion before surgery. The high-frequency array transducer Sonography with a high-frequency transducer is excellent in its resolution to evaluate skin lesions and is unaffected by infiltration of blood. Here, the authors report the use of ultrasound (color Doppler and pulse wave Doppler) for the diagnosis and management of CLC.An 18-year-old man presented 10 years previously with an asymptomatic 0.5 × 0.7 cm cluster of dark reddish vesicular lesions on his buttock. The lesions had recently increased in size and number. There was associated pachyderma. The lesions were hyperechoic and well defined on grayscale ultrasound and hypervascular on color Doppler ultrasound. Cluster cystics of lymphatic spaces were found throughout the whole dermis, especially in the papillary dermis. The lymphatic channels extended downwards to the reticular dermis and the superficial layer of the subcutaneous tissue. The pathological findings revealed lymphangiomas invading the subcutaneous tissue. The flat endothelial cells were partly positive for D2-40, which is a marker of lymphatic endothelial cells. Ultrasound was able to delineate the margins of the lesions. Diagnosis of CLC using preoperative color Doppler and pulse wave Doppler could reduce unnecessary repeated pre- and postoperative biopsies.

3. Lynphangioma Overview National Organization for Rare Disorders.

4. Micro- and Macrocystic Lymphatic Malformation. Lindsay McCormack, Krystal Jones, Jennifer T Huang. J Pediatr. 2020 Apr;219:275-276.  Free Full Text

 

5. Treatment of superficial vascular anomalies with topical sirolimus: A multicenter case series.  Melissa Dodds, et. al. Pediatr Dermatol. 2020 Mar;37(2):272-277.

Abstract: Background: Systemic sirolimus (rapamycin) has recently been found effective in treating complex vascular anomalies by reducing the size and associated complications. Many vascular anomalies have a cutaneous component, and thus, we sought to determine whether topical administration of sirolimus may be an effective therapy, as data on the use of topical sirolimus are limited.

Results: Eleven patients had combined venous lymphatic malformations, three had tufted angiomas, two had a lymphatic malformation, one had a venous malformation, and one had a verrucous venous malformation. All (100%) patients reported some degree of improvement and 50% of patients reported marked improvement in one or more symptoms, most commonly blebs and lymphatic drainage, and bleeding.

Conclusion: Topical sirolimus appears to be a safe and useful non-invasive therapy that is well-tolerated in the treatment of the cutaneous portion of a variety of vascular anomalies.

 

 

 

Monday, August 17, 2020

Lynphoepithelioma-like Carcinoma of the Skin


The patient, an 87 yo man in good general health, presented with a two month history of an asymptomatic papule in the right preauricular area.

The lesion was 7 mm erythematous papule without clinical or dermatoscopic diagnostic features.  There was an adjacent seborrheic keratosis.

A 4-mm punch biopsy was taken. 
Pathology:Aggregates of undifferentiated baseloid epithelium, some with central clear cell change and necrosis, associated with a peripheral rim of lymphocytes and scattered plasma cells.  In situ hybridization for EBV was negative.
These changes were interpreted as most consistent with a diagnosis of lymphoepithelioma-like carcinoma of the skin.
Thanks to Dr. Lynne Goldberg of Boston University Skin Pathology for the photomicrographs.
 

Re-excision:   
Although  an attempt was made to re-excise the lesion with 4 mm margins the patholoogy showed involvement of one lateral and the deep margin.
Appearance at re-excision

Diagnosis: Lymphoepithelial-like carcinoma of the skin (LECS).

ENT Connsult: No evidence of pharyngeal pathology
MRI: Normal with no adenopathy

The patient was referred for Mohs Micrographic Surgery.  The tumor was cleared with one stage, but a second stage was done to assure adequacy of excision.  (The patient's insurance was not charged for the 2nd stage).

Discussion:

Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare tumor of unknown etiology, low malignant potential, and microscopic resemblance to undifferentiated nasopharyngeal carcinoma. Clinically (as in this case), it presents as a flesh-colored firm nodule or plaque on the face, scalp, or shoulder of middle-aged to elderly individuals. Histologically, LELCS is composed of islands of enlarged epithelial cells with large vesicular nuclei surrounded and permeated by a dense lymphoplasmacytic infiltrate. LELCS exhibits immunoreactivity with high-molecular-weight cytokeratins and epithelial membrane antigen, indicating the epithelial origin.

Initially, the ENT consult felt that the patient should be referred to a radiotherapist for XRT; but the literature (see ref 3) does not support that.  He will be followed up at regular intervals by his dermatologist.

This case presentation highlights the difficulty in treating a rare disorder.  No one has enough expertise and one must fall back on the literature that may not be clear. Only about 80 of these tumors have been reported. Consultants may give opinions that are not based on science but on their own belief systems.  Where does the buck end?  The psychiatrist Michael Balint, described “The Collusion of Anonymity” in his book “The Doctor, His Patient and the Illness.”4  This holds that “the burden of responsibility is much too great, and everyone, including the patient, naturally tries to lighten it by involving someone else, or, if possible, a number of others. This may be described as the process of dilution of responsibility.

If all goes well with this collusion of anonymity all parties concerned feel justifiably proud and gratified. If anything goes wrong nobody is individually responsible.

The collusion of anonymity is one method of lightening the burden of responsibility. Present day practice in medicine is hardly more than the sum of the various specialties.

Nowadays everybody preaches that when a patient is ill the whole person is ill, not only his skin, stomach, his heart or his kidneys. This truth, while constant lip service is paid to it, is unfortunately ignored in most medical practices. A very experienced and disillusioned GP said, "nowadays it is enough for a doctor to know about 20 prescriptions and the address of about 30 consultants."

 


Reference
1. Bruce M Wenig. Lymphoepithelial-like Carcinomas of the Head and Neck. Semin Diagn Pathol. 2015 Jan;32(1):74-86.
Abstract: Lymphoepithelial-like carcinomas (LELC) of the head and neck represent malignant neoplasms that are histologically similar to nasopharyngeal carcinoma (NPC), nonkeratinizing undifferentiated type but arise in locations other than the nasopharynx. The most common location for LELC in the head and neck is the salivary glands, in particular the parotid gland. However, LELC may arise in other sites including the oropharynx (tonsils, base of tongue), sinonasal tract, larynx, and middle ear/temporal bone. Unlike the nonkeratinizing undifferentiated type of NPC which is etiologically linked to Epstein-Barr virus (EBV), LELCs are not uniformly associated with EBV. The differential diagnosis for LELC varies per site and depending on the site of occurrence may include lymphoepithelial sialadenitis, sinonasal undifferentiated carcinoma (SNUC), and large cell neuroendocrine carcinoma. Treatment general includes combined (multimodality) therapy including surgical resection, neck dissection, radiation therapy and/or chemotherapy. The prognosis may vary per site overall favorable owing to a good response to therapy.

2. Cristiano Claudino Oliveira, Vinicius Cardoso Nóbrega, and Mariângela Esther Alencar Marques. Lymphoepithelioma-like carcinoma of the skin*
An Bras Dermatol. 2018 Mar-Apr; 93(2): 256–258. Full Text: PMCID:PMC5916400
Abstract: Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.

3. Preston Q Welch. Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature (Review Article) Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jan;111(1):78-86.
Abstract: Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare tumor of unknown etiology, low malignant potential, and microscopic resemblance to undifferentiated nasopharyngeal carcinoma. Clinically, it presents as a flesh-colored firm nodule or plaque on the face, scalp, or shoulder of middle-aged to elderly individuals. Histologically, LELCS is composed of islands of enlarged epithelial cells with large vesicular nuclei surrounded and permeated by a dense lymphoplasmacytic infiltrate. LELCS exhibits immunoreactivity with high-molecular-weight cytokeratins and epithelial membrane antigen, indicating the epithelial origin. The differential diagnosis includes basal cell carcinoma, squamous cell carcinoma, lymphoma, pseudolymphoma, and Merkel cell carcinoma. We report 11 cases of LELCS of the head and neck region with discussion of the clinical, histopathologic, immunohistochemical, and therapeutic aspects of this rare cutaneous neoplasm. In addition, we systematically review and compare the findings with the previously published cases of LELCS. This study is the largest case series of LELCS reported in the English-language literature. It attempts to more clearly define the diagnostic criteria for LELCS. Its histomorphologic and immunophenotypic features help distinguish this tumor from similar-appearing malignancies, including metastatic nasopharyngeal carcinoma.
 
4. Michael Balint.  The Doctor, His Patient and the Illness. ChurchillLivingstone 1955.  For notes on The Collusion of Anonymity, contact D. Elpern who well email them to you.




Wednesday, June 24, 2020

A Case for Diagnosis

Presented by  Dr. Henry Foong, Ipoh, Malaysia

The patient, a Chinese woman in her 30s, presented with sudden flare of her skin eruptions on the legs past 2 weeks.  She had been having multiple erythematous plaques on the abdominal wall and legs since March 2020 and had tried various topical creams and oral supplements.  As it happened during lockdown she had tried online medications and topical creams.  The lesions on the abdominal wall improved but suddenly those on the legs flared up with painful pustules.  She denied any fever.  Apparently she was on oral methotrexate previously for psoriasis but according to her, MTX did not help her much.  

Clinical:
Her vital signs are stable. No signs of dehydration. 
Extensive erythematous plaques on the lower limbs.  Edges well demarcated. scaly surface. some of the larger lesions had a central smooth glazed appearance surrounded by crops of tiny superficial pustules.  Post inflammatory hyperpigmentation were prominent on the anterior abdominal wall.
No nail changes were noted.  Joints were normal.
Images:

Diagnosis:
Generalised pustular psoriasis of von Zumbusch

Note:  We presented a similar patient two years ago.

I suspect she may have taken oral corticosteroids and when she stopped the oral medications, the lesions flare up.  A skin biopsy was done.  This may be useful to exclude AGEP.  Blood counts/biochem/swab culture including serum calcium were done and pending.   
In the meantime, she is on IV fluids, IV antibiotics, topical moisturisers, KMNO4 soaks and topical corticosteroids.

Q1.  Would IV hydrocortisone be useful in this patient or avoided at all costs?
Q2.   Is it worthwhile to try MTX weekly dose again?  Cyclosporin? Oral acetretin would not be practical for a woman of child bearing age group. 
Q3.  Biologics may have a role.  Anti IL-36 recently was found to be useful in pustular psoriasis but this drug is not available yet.  Which other biologics would be useful? Risankizumab?

Thank you for your thoughts on this patient.

Monday, June 22, 2020

Angiokeratoma of the Vulva


The patient is a 32-year-old woman who was seen today for lesions on the vulvae.  She saw a gynecologist because one of them was bleeding and he told her that they were cherry angiomas and that she should see a dermatologist. 
  
EXAMINATION:  The examination shows a pleasant, moderately obese woman.  On the vulva, she has scores of purple papules measuring 1-2 mm in diameter. 
    

Photo
IMPRESSION:  These are angiokeratomas of the vulvae.  They are different from cherry angiomas.  There was one lesion that has been occasionally bleeding although today is quiescent.  I could remove that with ED&C when it becomes more active. 

Reference:
1. Angiokeratoma of the Vulva
[Article in English, Portuguese]
Leticia Fogagnolo  1 , et. al 
An Bras Dermatol Mar-Apr 2011;86(2):333-5. PMID: 21603817
Abstract: Angiokeratomas are benign tumors characterized by ectasia of blood vessels in the papillary dermis associated with acanthosis and hyperkeratosis of the epidermis. Dermatological examination of angiokeratomas of Fordyce is characterized by papular keratotic lesions of erythematous-violet color. They are more common in the scrotum, and vulvar involvement is rarely reported. Histopathology is particularly important to distinguish them from other benign and malignant tumors. The article reports the case of a middle-aged black woman with a history of chronic constipation, varicose veins of the lower limbs and cesarean section performed 20 years ago who had had multiple vulvar angiokeratomas for three months.



Friday, June 12, 2020

She’s Not Handling This Well


The patient is a 65 year-old woman with a two-month history of hand dermatitis.  She has had no new medications in a year and has been laid off from a job in sales due to Covid 19.  After 25 years, she’s had to sell her house and is moving into an apartment in three days time.  Holding up her hands up in front of her, without irony, she said, “I’m not handling this situation well.”


Clinical Exam: The palms of both hands are dry with marked scale plates.  The dorsae of the hands are normal.  There are no other cutaneous findings.  In the photo above, there is a suggestion of Dennie-Morgan Lines.  Her feet are normal.


Discussion:  In the differential diagnosis I considered traumiterative hand dermatitis, psoriasis, contact dermatitis, tinea (KOH was negative).
But I keep wondering about that phrase in English, “She can’t handle it.”  Why is that aphorism there?  Did the Ancients know something we’ve forgotten?

She will be treated with clobetasol ointment employed with a “Soak and Smear” protocol.  If she does not clear by a few weeks after her move, biopsy, patch testing, and a medical workup will be pursued, but she has other things on her plate just now.

Monday, May 25, 2020

~ 4000 Times the Price of Gold


I made a house call on an 90 year old patient yesterday.  He lives with his wife in an idyllic house surrounded by vernal gardens and a wetland preserve.
 
The patient was presented on VGRD in 2014 with a desmoplastic melanoma of the scalp that measured > 7.5 mm thick.  Since that time, he has done reasonably well.  A metastatic lymph node was excised from the r. preauricular area ~ 4 years ago.  He was doing well until early May, 2020 when he developed right upper quadrant pain.  The ER work-up suggested non-ST-elevation myocardial infarction (NSTEMI) and he was admitted to a local hospital.  There, elevated LFTs were noted and scans confirmed presence of multiple liver masses (largest being 3 cm diameter) and enlarged mesenteric lymph nodes (largest 3.6  cm diameter). A supraclavicular l.n. was biopsied that showed metastatic melanoma.
Significant co-morbidities include recent osteomyelitis (left foot) for which he is currently on oral medication (doxycycline), HTN, gout and the recent NSTEMI, and ischemic cardiomyopathy with a depressed EF (25-30%).
Medications: metoprolol, lisinopril, Plavix, Lipitor, allopurinol, and ASA

He is a high functioning nonagenarian who lives independently with his wife and until the past few months was doing well.

His oncologist is recommending Ketruda (pembrolizumab).  When I spoke with the patient a few days ago he told me that the oncologist said Ketruda was well-tolerated, but when I checked the oncologist’s notes the recorded discussion of side-effects ran 12 lines on the office note. 
Yesterday, the patient gave me a printout he independently made.  After he and his wife read it, and he now has doubts.  His quality of life is good, he enjoys his home, meals, and an occasional dram of Johnny Walker Black… he spoke of quality of life over a few extra months.  He’s done all he wanted to do in life.
We plan to sit down this week in my office and have a more formal discussion.

His metastatic lesions were discovered incidentally as a result of hospitalization for his NSTEMI.  Is this a good sign that pembro will be helpful, or at this time do the risks outweigh the benefits?  When the randomized studies were done with pembro, were nonagenarians with cardiomyopathy or significant co-morbidities excluded?
Your thoughts will be appreciated. 

Postscript: A week after I saw him, he had a PET scan.  The next day, he developed profound weakness. He took to his bed.  Stopped eating and drinking.  He became stuporous and died two days after the scan attended to by his loving wife and a caring nurse.  The day after he died, his oncologist called with the PET scan results.  His liver was entirely replaced with tumor.  He told her that Ketruda was not indicated in such a situation.  He lived reasonably well until two weeks before he died.

Reference
1. Few people actually benefit from ‘breakthrough’ cancer immunotherap
y
By
Nathan Gay and Vinay Prasad. March 8, 2017. Stat Topics.  [We will try to see if the authors still believe this]

2. Alyson HaslamVinay Prasad  Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs. JAMA Netw. 2019 May 3;2(5):e192535.  Free Full Text at PMC.
3. Madhuri Bhandaru, Anand Rotte  Monoclonal Antibodies for the Treatment of Melanoma: Present and Future Strategies. Methods Mol Biol. 2019;1904:83-108.  A Review

 




Sunday, May 10, 2020

Hairband Alopecia in a Covid Carer

May 8, 2020
Dr. Z. is a 30 year-old ophthalmology resident called to duty on the Covid ward of a large East Coast metropolitan hospital where over a 1000 Covid patients had been treated to date.  In this age of telemedicine, she wrote me the following:
“Our community was hit hard by this pandemic, and we continue to help out on the Covid floors. It’s been a scary and yet rewarding experience!
I want to ask your opinion regarding a dermatology question! Last night I noticed a small patch of hair missing. I think it was in the area where I was wearing a tight hairband while in the hospital about 3 weeks ago. I had the hair band on for four days. It was so tight that the area would hurt when I took it off at night after a long shift. I just didn’t want any hair in front of face on Covid ward. I was wondering if there is anything I need to do about it? Or just wait for it to grow out. The scalp area looks a little red, here are two photos.”















While this appears to “pressure alopecia,” I offered to run Dr. Z.’s anamnesis by a colleague with a special interests in disorders of hair.  How we practice now is different from a few months back.  We will be seeing new variations on a theme such as perhaps, Hairband Pressure Alopecia.

References:
1. Sano DT, et. al. Headband pressure alopecia: clinical, dermoscopy, and histopathology findings in four patients. Int J Dermatol. 2018. Feb;57(2):237-239

2. Iwai T, et. al. Temporary alopecia caused by pressure from a headband used to secure a reference frame to the head during navigational surgery. Br J Oral Maxillofac Surg. 2009 Oct;47(7):573-4. 

We consulted with a dermatologist nationally recognized specialist interest hair disorders.  She responded “I do not have much experience with pressure induced alopecia, likely because the etiology is apparent and it regrows in most cases. The photos do suggest pressure alopecia, although there is a differential for patchy alopecia including alopecia areata and tinea capitis. As you know, the current theory is that it is ischemic in nature. I wonder how tight the headband was! Her area of loss is small and it looks rather non-inflammatory, so one would think prognosis for regrowth would be good. It can take a couple of months to see new sprouting hair shafts. Scarring can occur if the insult is severe or prolonged – this can sometimes result in ulceration which is not present."
 

Monday, April 27, 2020

Hailey-Hailey Disease masquerading as Recurrent "Tinea cruris"

Dr Henry Foong
Ipoh, Malaysia

The patient, in his 50s, presented with a 10-year history of  recurrent pruritic skin eruptions on the groins and axilla. He was treated by his GPs as well as a urologist for "infected tinea cruris" with oral antifungals, IV antibiotics, topical steroids, topical antifungals but the treatments did not help. For the past 3 months, the lesions have worsened. He had no fever or other constitutional symptoms.  He had no history of diabetes. His father apparently had similar skin lesions. 

Examination showed erythematous plaques with vesiculation and superficial fissures and erosions on the groins extending to the scrotum, inner thighs and intergluteal cleft. The lesions appeared to be bilateral, symmetrical, hyperpigmented and well demarcated. Similar lesions were noted on the axilla. There were no bulla or purpura. There was no oral or nail lesions. KOH exam for hyphae was negative on 3 occasions.

Initial provisional diagnosis was that of tinea incognito but KOH exam was repeatedly negative.  Hailey-Hailey disease a.k.a. familial benign chronic pemphigus was considered in the differential diagnosis.  





A skin biopsy with DIF was done.  H&E shows focal and central lesion of suprabasal and intraepithelial clefts containing basophilic cells with large nuclei and a paranuclear halo.  There is a presence of basal keratinocytes attached to basement membrane forming a characteristic tombstone, or ‘‘dilapidated brick wall’’ appearance. Corps ronda cells are not prominent. The stratum corneum shows parakeratosis and hyperkeratosis with focal neutrophilic infiltrates.  The upper dermis shows perivascular infiltrate of lymphocytes, histiocytes and eosinophils.
Immunofluorescence studies show IgG, IgA , IgM, C3 were negative.

Interpretation: Acantholytic epithelial lesion consistent with familial benign pemphigus.



The management of this patient may be challenging.  General measures such as wearing lightweight and loose clothing would be helpful.  Avoiding friction on the affected areas, use of mild antiseptic solutions  and reduction in sweating are also advisable. In terms of specific treatment, we plan to start with topical calcineurin inhibitors and oral antibiotics such as doxycycline 100mg bd. Other possible options include low dose naltrexone, methotrexate, dapsone, azathioprine, etanercept, apremilast, botox and laser treatment.  Low dose naltrexone appeared to be very effective in some of the cases but may have variable responses according to the dose.

References
1. Imene Ben Lagha, Kurt Ashack, Amor Khachemoune.  Hailey Disease: An Update Review with a Focus on Treatment Data.American Journal of Clinical Dermatology Oct 2019.  https://doi.org/10.1007/s40257-019-00477-z
2. Hohl D. Darier disease and Hailey–Hailey disease. In: Bolognia J, Jorizzo J, Schaffer J, editors. Philadelphia: Elsevier Inc; 2012. p. 887–97.
3. Severine Cao, Evelyn Lilly, Steven T. Chen. Variable Response to Naltrexone in Patients With Hailey-Hailey Disease. JAMA Dermatol. 2018 Mar; 154(3): 362–363. 

Monday, April 06, 2020

68 year-old woman with subcutaneous lesions

Presented by Dr. A.R. Pito, Retired, Volunteer Dermatologist
Queens Memorial Medical Center
New York, New York

This 68-year-old woman presented for evaluation of painful lesions under the skin that have been present for 3-4 months. She has a history of psoriasis, which is in remission, fibromyalgia, hypertension.  There is no personal history of malignancy.  No exotic travel.  She had smoked over two ppd for decades.

EXAMINATION: The examination shows a woman who appears slightly older than her stated age. She has 6-8 freely movable subcutaneous smooth-surfaced lesions on the back, posterior nuchal area, and the upper chest. The largest is ~ 5 mm in diameter. The remainder of the exam plus breast palpation was unremarkable.  No adenopathy appreciated.


INITIAL MPRESSION: Subcutaneous skin lesions, present for only a short period of time. Etiology is unclear.

PLAN: An excisional biopsy was taken today from the lesion on the right upper back.

Pathology: 
The first two are H&E of nodule in the fat, showing atypical cells with duct-like vacuoles. The second two are representative immunoperoxidase stains. GATA 3 is the nuclear one (dot-like pattern) and mammoglobin is the cytoplasmic staining.
These darkly beautiful photomicrographs were taken by Dr. Lynne Goldberg at the Boston University School of Medicine's Department of Dermatopathology.



Plan:  Mammography and breast ultrasound. Referral to oncologist.
Mammography shows masses in r. breast.  Ultrasound guided biopsy planned and specimen will be sent for Estrogen receptor, progesterone receptor and Her-2 (human epidermal growth factor receptor).

Note:  In this age of "Social Distancing" it is unlikely that this disgnosis would have been make expeditiously in a woman with no history of an underlying malignancy.  We will add more as her case progresses.

Your thoughts will be appreciated.

References:
1. Mammaglobin, a Valuable Diagnostic Marker for Metastatic Breast Carcinoma Zhiqiang Wang1, et. al. Int J Clin Exp Pathol (2009) 2, 384-389
Abstract:  Identification  of  metastasis  and  occult  micrometastases  of  breast  cancer  demands  sensitive  and  specific  diagnostic  markers.  In  this  study,  we  assessed  the  utility  of  a  mouse  monoclonal  antibody  to  human  mammaglobin  for  one  such  purpose.  Immunohistochemical  stains  were  performed  on  paraffin-embedded  sections  from  a  total  of  284  cases,  which  consisted  of  primary  breast  invasive  carcinomas  (41  cases)  with  matched metastases to ipsilateral axillary lymph nodes, metastatic breast carcinoma to liver (1 case) and kidney (1 case), non-breast neoplasms (161 cases), and normal human tissues (39 cases). The results showed 31 of the 41 cases of primary breast cancer with axillary lymph node metastases were positive for mammaglobin (76%). In the meantime, we documented expression of mammaglobin in occasional cases of endometrial carcinoma (17%). Our data further validated that mammaglobin is a valuable diagnostic marker for metastatic carcinoma of breast origin, although endometrial carcinoma should be considered as a major differential diagnosis. 

2. GATA3 Expression in Common Gynecologic Carcinomas: A Potential Pitfall. Tatjana Terzic  et. al.  Int J Gynecol Pathol, 38, 485-492 2019
Abstract: GATA binding protein 3 (GATA3) immunohistochemistry is primarily used as a marker of breast and urothelial differentiation, particularly in metastatic settings. In the gynecologic tract it also serves a robust marker for mesonephric and trophoblastic tumors. Full Abstract: pubmed.gov PMID: 30059453