Thursday, December 24, 2015

Post-Auricular Basal Cell


The patient is an 84 year-old man with a one to two week history of bleeding from a lesion in the sulcus behind the left ear and overlying the mastoid process.  He had noticed a tumor there for a longer period of time and has covered that with a Band-aid.  The area was recently traumatized and he was seen at the Dermatology Clinic. He has a history of basal cell carcinoma of the glabella.

O/E:  There is a 2 cm erosive lesion behind the left ear that extends over the mastoid bone. 

A shave biopsy was taken from two representative areas.

Clinical Photo:
Pathology:  Basal cell carcinoma. Probably nodular, but deeper areas may show other features

Diagnosis:  The pathology confirms the clinical impression of basal cell carcinoma.

Discussion:  This is a particularly worrisome area.  While some nonmelanoma skin cancers in octogenarians can be observed, lesions in this area can be invasive into the underlying bone.  For this reason, we will recommend Mohs micrographic surgery.

Reference:
Invasive basal cell carcinoma of the temporal bone.
Gussack GS et. al.
Abstract: Basal cell carcinomas involving the ear represent a spectrum of diseases, from a small superficial auricular lesion to an advanced destructive malignancy invading the temporal bone. The biologic activity of the morphea-form basal cell carcinoma variant of tumor and a postauricular location predispose to an aggressive biologic pattern. Management requires a thorough evaluation with determination of the degree of cranial and possible intracranial invasion. These lesions usually can be managed with partial temporal bone resections, although prognosis for patients with advanced lesions may be poor.
(No proof of bone invasion in this case; however, this is a setting where one needs to consider it)

Sunday, December 20, 2015

Towards Continuous Medical Education


With VGRD, since the year 2000, we have tried to provide a new paradigm of CME.  At its best VGRD provides Continuous Medical Inspiration (CMI).  This platform preceded the landmark article by Roni Zieger that we introduce you to here:


Toward Continuous Medical Education (Free Online Full Text)
Roni F Zeiger, MD. J Gen Intern Med. 2005 Jan; 20(1): 91–94.
Abstract:
While traditional continuing medical education (CME) courses increase participants' knowledge, they have minimal impact on the more relevant end points of physician behavior and patient outcomes. The interactive potential of online CME and its flexibility in time and place offer potential improvements over traditional CME. However, more emphasis should be placed on continuing education that occurs when clinicians search for answers to questions that arise in clinical practice, instead of that which occurs at an arbitrary time designated for CME. The use of learning portfolios and informationists can be integrated with self-directed CME to help foster a culture of lifelong learning.

Keywords: continuing medical education, Internet, distance learning, library services

Sunday, December 13, 2015

Perplexing Recurrent Cheilitis


Presented by Henry Foong
Ipoh, Malaysia
 
Abstract: A 20-year-old man presented with recurrent cheilitis 

HPI: A 20-year-old student presented with recurrent peeling of the lips for about 3 years. It usually began on the upper lip then involved the lower lip. Then the cycle repeated. The entire process takes about 3 weeks. He has no known drug allergy. He denied any lip smacking. He was using a moisturising non-SLS tooth paste.

Examination showed peeling of the lower and upper lip as a single friable sheet. His oral cavity and genitalia were unremarkable.

Clinical Images


Patch Tests:                                 
Gold sodium thiosulphate  ++ at 48 and 96 hours;
Iodopropynyl butylcarbamate  + at 48 and – at 96 hours
Sodium bisulphide + at 48 and 96 hours
Thimerosal +/- at 48 and 96 hours

Histopathology: The sections show a fragment of tissue surfaced by parakeratinised stratified squamous epithelium. The underlying connective tissue is moderately collagenous with mild chronic inflammatory cells infiltration and a few small blood vessels. A few lobules of minor salivary glands are observed. No granuloma seen in the sections examined. Final Path Diagnosis: Lower labial mucosa: Histologically non-specific 

Diagnosis: Chronic cheilitis

Reason for presentation  
Despite avoiding all the trigger factors such as lip smacking and use of non-SLS toothpaste, his symptoms persisted. The patch test results are probably irrelevant in his case. In a study from Singapore, toothpastes were the commonest cause of allergic contact cheilitis in males. Ricinoleic acid and the patient's own lip preparations were the commonest relevant contact allergens. The absence of granuloma practically make granulomatous cheilitis unlikely.


Questions   
What is the most likely diagnosis? Could this be a case of exfoliative cheilitis? Exfoliative cheilitis, a rare, localized condition, is a chronic superficial inflammatory condition that is characterized by regular peeling of a superficial excessive layer of keratin. the cause of this condition is unknown but may be associated with depressive illness. Two other differential diagnosis comes to mind - pemphigus vulgaris and Crohn's disease.

References
1. Mani SA, Shareef BT. Exfoliative cheilitis: report of a case. J Can Dent Assoc. 2007 Sep;73(7):629-32. AbstractFull Free Text.

2. Lim SW, Goh CL. Epidemiology of eczematous cheilitis at a tertiary dermatological referral centre in Singapore.Contact Dermatitis. 2000 Dec;43(6):322-6. Abstract.

3.  Contact allergy in cheilitis.  O'Gorman SM, Torgerson RR.  Int J Dermatol. 2015 Nov 6.  Abstract. (See Dr. Sharquie's comments)

4. Exfoliative Cheilitis DermNet-NZ. (excellent synopsis)

Keywords   
chronic cheilitis, exfoliative cheilitis


Monday, November 30, 2015

Sarcoidal Granulomas

Presented by Christine Shanahan, Third Year Student
University of Virginia School of Medicine

Abstract: 36 yo male with diffuse erythematous pruritic plaques

HPI: The patient is an uninsured 36 yo male with a 6 month history of diffuse erythematous pruritic plaques on the chest, back and buttocks. The condition worsened over the past 2 months. He has no history of prior skin diseases, diabetes mellitus or other systemic conditions. He denies shortness of breath, wheezing, chest pain, eye problems, night sweats, unintentional weight loss or fatigue. He usually receives medical care in South America and frequently travels between South America and the United States.


On Examination: Diffuse erythematous pruritic plaques present on the chest, back and buttocks. No evidence of eyelid margin or oral cavity involvement.

Clinical Images:


 

Lab:
Chest radiograph showed no abnormalities.
Serum angiotensin-converting enzyme (ACE) level was found to be normal.
Recommended undergoing pulmonary function tests, ophthalmologic exam and chest CT scan.


Pathology:
Punch biopsy specimen from mid-back revealed numerous well-formed epithelioid cell granulomas in various levels of the dermis, a few patchy lymphocytic infiltrates and no necrosis or suppurative inflammation. No evidence of infectious microorganisms were found with special stains for acid-fast bacilli and fungi. Second pathologist evaluated specimen and confirmed diagnosis. Tuberculoid type of Hansen’s disease was added to histologic differential diagnosis but Fite stain showed no M. leprae.


Diagnosis: Sarcoidal granulomatous inflammation consistent with Sarcoidosis.


Plan: The patient was counseled on the importance of screening tests, including pulmonary function tests and an ophthalmologic examination, due to the insidious onset of systemic sarcoidosis and the frequency of pulmonary and ocular manifestations. The patient was reluctant to have any further workup beyond treatment of the skin condition. He was treated with 1 cc of intramuscular triamcinolone acetonide 40mg/cc (kenalog®-40) and topical steroids at follow-up visit. He was scheduled for follow-up visit in 1 month and referred for further workup of systemic disease.


Discussion:
Early diagnosis of sarcoidosis can be difficult, so cutaneous lesions can be key findings in helping to expedite this diagnosis.  Cutaneous sarcoidosis occurs in 20% to 35% of patients and can present at the early onset of disease. Also, skin involvement has been associated with more rapid progression of systemic sarcoidosis. The skin manifestations are described as specific or nonspecific lesions and are usually asymptomatic with pruritus in about 10% of patients. This patient had pruritic specific lesions with noncaseating granulomas visualized as plaques, one of the various typical morphologies. Although this patient appears to be in the early stages of the disease, the plaque presentation is typically associated with chronic forms of systemic disease. Sarcoidal lesions can mimic many other conditions including Hansen’s disease, leishmaniasis and lupus vulgaris. Specifically, tuberculoid type of Hansen’s disease is histologically similar and “the Fite method” is commonly used to distinguish the diseases. Cutaneous leishmaniasis remains endemic to many countries in South America such as Brazil, Colombia and Peru. The histopathology may be similar to sarcoidosis and some recent recommendations have been made to order PCR for Leishmania-specific DNA for any presentation of sarcoidal type granulomas in patients living in endemic areas


Questions:
  1. Could this still be Hansen’s disease with a negative Fite stain?
  2. Could this be a form of Leishmaniasis?
  3. Any recommendations for further workup of sarcoidosis for a low-income, uninsured patient?  

    References:
    1) Cutaneous sarcoidosis: differential diagnosis
    Clinics in Dermatology, Volume 25, Issue 3, Pages 276-287
    Esteban Fernandez-Faith, Jonelle McDonnell
     
    2) Hansen's Disease: An Imitator of Cutaneous Sarcoidosis
    Katsuya Chinen
    , Kazuhiko Hirano, Yasunori Fujioka
    Pictures in Clinical Medicine. Internal Medicine Vol. 50 (2011) No. 19  P 2257-2258

    3) Comorbidity of Leishmania Major with cutaneous sarcoidosis 
    Moravvej H, Vesal P, Abolhasani E, Nahidi S, Mahboudi F.
    Indian Journal of Dermatology. 2014;59(3):316. Free PMC Article 

    4. The Sarcoid-Lymphoma Syndrome. (MedScape) 

Sunday, November 22, 2015

Drug-Induced Lupus?


There are more things in heaven and earth then I dreamt of in our philosophy; and more things that we encounter in our offices than we can find in PubMed’s> 20,000.000 citations.

 A 35-year-old woman was started on a second course of isotretinoin for recurrent acne. Her previous treatment was two years earlier and was uneventful.  A few weeks after restarting the medication, at a dose of 0.5 mg per kilogram per day, she experienced some malaise, muscle aches, and mild joint pain. There were no new skin findings. She called me and I allowed that I had not heard of these symptoms with isotretinoin, but ordered a CBC and an ANA.

The CBC was normal, but the ANA was positive at 1:640 with a homogeneous pattern.   A PubMed search retrieved no references to drug-induced lupus and isotretinoin. However, a Google search found some anecdotal reports and a few cases of suspected DIL with isotretinoin (there were 5 alleged cases of DIL out of 27,831 self- reported isotretinoin side-effects) eHealthme.

With regards to our patient, I am going to repeat her ANA and obtain an anti-histone antibody test. If the ANA is still positive I will have her stop the isotretinoin and repeat the lab studies after 2–3 weeks. Should this likely be DIL then I think it is important that there be a report in the medical literature as undoubtedly other patients will experience this.

Saturday, November 21, 2015

Dermatoscopic Pointillism


The patient is a 45 yo woman who presented with a new lesion on the right malar eminence.  It looked innocuous, perhaps, a lentigo.  The dermatoscopic image revealed a pointillist pattern.  One of our VGRD members, Dr. Phung Huynh described “pointillist nevus” some years ago.  While this is not a nevus, it shows a similar pattern.

A 3 mm punch biopsy was taken to establish what this lesion is and it is being presented for interest since I could find no reference to this phenomenon in PubMed.
For Art's Sake
Pathology: The biopsy shows a focal lichenoid lymphocytic infiltrate, scattered colloid bodies and melanophages consistent with lichen planus-like keratosis (LPLK).

 
Reference:
1. Pointillist nevi.
Huynh PM, Glusac EJ, Bolognia JL. J Am Acad Dermatol. 2001 Sep;45(3):397-400. PubMed.

2.  Dermoscopy of lichen planus-like keratosis: a model of inflammatory regression.  Bugatti L, Filosa G. J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1392-7.  PubMed.


Saturday, November 14, 2015

Recessive Dystrophic Epiermolysis Bullosa


We were sent the following case from Romania for suggestions.
Speranta is a 36 year-old woman from Romania who was diagnosed with Recessive Dystrophic Epidermolysis Bullosa (RDEB) at age of 6.  Initially vesicles appeared on the hands and body and then erosion and ulceration with mutilation of hands and feet. The lesions presented on the oral mucosa too. She also has difficulty with swallowing as oral feeding seems to exacerbate the lesions within the mouth. Currently the patient is cachectic. She was born in Romania and came to Germany to visit for 3 weeks. She presented in 2008 at the urgent clinic. She was referred to Freiburg University Clinic (specialized in EB) but due to the cost she was not able to stay and be treated. She does not have health insurance and she is treated only on emergency basis. For several days she has severe pain from her mutilated hands. She was treated with Flamexin powder (piroxicam) and with antiseptics. She c/o fever and chills. Over the course of the evaluation there was evidence of lesions of up to 10cm diameter, deep and greasy ulcerations, erythema and crusts on the torso, gluteal , V neck area, arms , legs and feet. There are mutilations on her feet but more severe on the hands, the fingers are unrecognizable. She has microstomia, her oral mucosa has multiple small erosions. Opening of mouth is almost impossible. Has multiple crusts over scalp.
 Bacteriology: from torso: stafilococus, multiple.  From feet and hands ulcerations: massive staf aureus.
This was a temporary inpatient visit for a patient who presented with severe pain and cachexia secondary to BE involving mucosa. She was treated with topical antiseptics and antibiotics, "antiseptic showers" and degreasing the integuments. Oral mucosa was washed with pantenol and external antiinflamtory. Due to urgent/temporary treatment and lack of insurance, genetic testing and a skin biopsy were not done. She received Clindamycin 300mg bid and due to severe pain the anesthesiologists were consulted.
Recommendations were for: a topical treatment with antibiotics: Fucidine unguent, Lomatuell, Mepithel. Oral swishes with pantenol. The pain medication to be adjusted as needed, high caloric intake d/t cachexia and control the abnormal lab values.

Social History: After she was diagnosed at age 6 Speranta was hospitalized multiple times for prolonged periods of time in hopes of finding a cure for her disease. One day when she was 16 yo she tried commit suicide by drinking a bottle of pills but her parents found her in time. Currently, she is married, bur her husband is gone most of the time from home because of his job. She is the primary care giver for her 2 little nephews (orphans from both parents) and for her sick mother and paralyzed father. What keeps her from committing suicide is that she needs to take care of her parents and these children.  Presently, she wants to be able to continue to afford her palliative medications and dressings that help her reduce the debilitating pain she has on a daily basis.  

Comment:  A few years back, we say a documentary, The Boy Whose Skin Fell Off. It was dramatic and memorable.  The woman presented here, at age 36, is lucky that she has not had invasive squamous cell carcinoma yet.  Her life must have been one long story of pain.  While we know a bit about her physical disease, we know nothing about her family or how she has managed to cope.  We suspect that her story may shed some light on her quality of life. 
 
A few of our VGRD members have a special interest in this disorder and their comments will be welcome.

Film:  Here is a link to a You-Tube of The Boy Whose Skin Fell Off. (2004, 49 minutes)

Friday, November 06, 2015

Macular and Papular Eruption in a Young Child


Two year old boy with papular eruption since birth.

HPI: The patient is a 2-3/4 year old child who presents for evaluation of lesions on the torso and face, hat have been present since birth.  Initially, the lesions were on his left TMJ area and they have generalized since then. 

The child has had many ear infections and now has tubes.  Otherwise, he has been healthy.  On direct questioning, his mother states that the lesions become red after a bath. 

O/E:  The examination shows a healthy-appearing boy. He has tan macules on the left TMJ, on the chest, the back, and a few lesions on the legs.  The lesion measure 2-4 mm in diameter.  After stroking, they appeared to urticate. 

Clinical Photos:


IMPRESSION:  This is most likely maculopapular cutaneous mastocytosis, otherwise known as urticaria pigmentosa.

Discussion:  The child is very apprehensive and the question is whether a biopsy should be done or should one observe him.  He seems healthy and at present not troubled by his lesions.  



Reference:
1. Severity of cutaneous findings predict the presence of systemic symptoms in pediatric maculopapular cutaneous mastocytosis.
Barnes M1, Van L, DeLong L, Lawley LP. Pediatr Dermatol. 2014 May-Jun;31(3):271-5.  Abstract: Although the prognosis of maculopapular cutaneous mastocytosis (MPCM), also referred to as urticaria pigmentosa, is often benign, clinicians lack evidence to reliably predict those at risk of associated systemic manifestations. We sought to elucidate clinical markers of disease severity to provide better treatment and prognostic information for individuals with MPCM. A retrospective chart review querying characteristics of children diagnosed with MPCM in the Emory Dermatology Clinic was performed. Follow-up was obtained through a clinical encounter or telephone interview. Linear regression was used to determine predictors of the number of MPCM-related systemic symptoms. Of 67 subjects, 57% were male, and the mean age of onset was 4.5 months. The maximum number of MPCM lesions was 1 to 10 in 16%, 11 to 30 in 33%, 31 to 50 in 25%, 51 to 100 in 6%, and more than 100 in 20% of subjects. For their MPCM lesions, 46% of subjects reported itching, 34% flushing, and 25% blistering. Reported systemic symptoms included diarrhea (22%), abdominal pain (15%), wheezing or dyspnea (13%), vomiting (10%), bone pain (10%), headaches (8%), cough (10%), rhinorrhea (8%), irritability (6%), and anaphylaxis (1.5%). In a multivariate linear regression analysis, the maximum number of MPCM lesions (p = 0.02) and the number of skin symptoms (p < 0.01) were statistically significant predictors of the number of systemic symptoms, controlling for age of onset, body sites involved, and sex. The correlation between cutaneous findings and symptomatology could aid clinicians in identifying individuals with MPCM who might warrant systemic evaluation and therapy.

2.  Review Article: Mast Cells, Mastocytosis, and Related Disorders
Theoharis C. Theoharides, Ph.D., M.D., Peter Valent, M.D., and Cem Akin, M.D., Ph.D.

N Engl J Med 2015; 373:163-172July 9, 2015

Dr. Theoharides reports receiving royalties from a patent (US 8,268,365 B2) related to an antiinflammatory composition for treating brain inflammation, licensed to Algonot (a portion of the proceeds is given to Tufts University under an agreement and another portion is given to to AutismFreeBrain, a nonprofit company for autism research). He also reports holding a patent (US 7,906,153 B2) related to mast cells, antiinflammatory agents, multiple sclerosis, central nervous system disorders, and a mixture of flavonoids and olive extracts, a patent (US 7,799,766 B2) related to the treatment of hormonally dependent cancers, and a patent (US 6,689,748 B1) related to a method of treating mast-cell activation–induced diseases with a proteoglycan that is licensed to Algonot. Dr. Valent reports receiving grant support from Ariad Pharmaceuticals, Celgene, Bristol-Myers Squibb, Pfizer, Novartis, and Blueprint Medicines. Dr. Akin reports receiving consulting fees from Novartis, Patara Pharma, and Blueprint Medicines and royalties from a patent (WO2003065986 A2) related to the Laboratory of Allergic Diseases 2 mast-cell line. No other potential conflict of interest relevant to this article was reported.
(I can send a pdf of this article to anyone who asks.  DJE)


3. Guidelines for the Diagnosis and Treatment of Cutaneous Mastocytosis in Children
Mariana Castells, MD,* Dean D. Metcalfe, MD,** and Luis Escribano, MD, Am J Clin Dermatol. 2011 Aug 1; 12(4): 259–270.
This excellent article is available Free Full Text online.
 

Friday, October 09, 2015

Pustular Folliculitis

The patient is a 32 yo man with a 5 year history of an inflammatory process of the mid-upper chest.  He is in good general health and takes no medications by mouth.

The eruption is comprised of discrete papules and pustules.  No areas other than those seen in the photos are involved. Hair growth in the area is unaffected.


Lab:  Culture grew out only Coagulase Negative Staph 1+

Pathology:  The specimens exhibit a dense perifollicular neutrophilic infiltrate forming abscesses and infiltrating follicular epithelium, with admixed lymphocytes, plasma cells, and histiocytes. The histologic differential diagnosis includes both inflammatory and infectious causes of folliculitis. GMS and PAS stains are negative for fungal organisms. Tissue gram stain is negative for bacteria.

Discussion:  This is a healthy young man with a five year history of a localized folliculitis on his chest. If this was fungal, one would expect some hair loss or progression over five years. I found a similar case on PubMed that fit the history, clinical and pathological findings (see below); but still have some questions.  Any suggestions will be appreciated.

Diagnosis: Folliculitis, etiology unclear.  Consider Majocci.

Reference:
Tinea corporis gladiatorum presenting as a majocchi granuloma.

Kurian A1, Haber RM.  ISRN Dermatol. 2011;2011:767589.  Free FullText.
Abstract: Background. Wrestlers are at increased risk of developing cutaneous infections, including fungal infections caused by dermatophytes. Erythematous lesions due to tinea infections can be mistakenly diagnosed as an inflammatory dermatitis and incorrectly treated with potent topical corticosteroid treatments which cause localized skin immunosuppression. This can eventuate in a Majocchi granuloma which then becomes refractory to topical antifungal therapy. To our knowledge, this is the first case of tinea corporis gladiatorum presenting as a Majocchi granuloma. Observations. A 20-year-old wrestler presented with a 4-year history of a large pruritic, scaly erythematous plaque with follicular papules, and pustules on his right forearm. The lesion had the clinical appearance of a Majocchi granuloma. He had been treated with potent topical corticosteroids and topical antifungal therapy. KOH and fungal culture of the lesion were negative. An erythematous scaly lesion in the scalp was cultured and grew Trichophyton tonsurans. Oral Terbinafine therapy was initiated and complete resolution of both lesions occurred within 6 weeks. Conclusion. The purpose of this report is to inform dermatologists that tinea corporis gladiatorum can present as a Majocchi granuloma and needs to be considered in the differential diagnosis of persistent skin lesions in wrestlers.









Thursday, October 01, 2015

Unusual Vascular Pattern

28 yo man with progressive vascular anomaly of both legs.

History:  The patient is an otherwise healthy 28 years old man with a life-long history of superficial blood vessels of both lower extremities.  This is spreading centripetally. It is painful and has a burning sensation.  No history of edema or ulceration.  No family history.

O/E:  Both lower extremities show prominent superficial arborizing blood vessels.  The red color suggests these are arterioles.  There is no evidence of hemosiderin deposition.

Clinical Images:


Pathology:  A 4 mm punch biopsy was taken.
The specimen exhibits dilated superficial blood vessels surrounded by PAS positive amorphous pink hyaline material. This is consistent with cutaneous collagenous vasculopathy. 
Histopathological Photos taken by  

Hyejin Leah Chung, Dermatopathology Fellow at Boston Medical Center

1. low magnification with dilated superficial blood vessels (H&E, x10)


2. higher magnification with dilated superficial blood vessels surrounded by amorphous pink hyaline material (H&E, x20)


3. PAS stain highlights the amorphous pink material. (PAS, x 20)

Diagnosis:  This does not fit any disorder I have seen. The diagnosis of cutaneous collagenous vasculopathy is interesting.  I think generalized essential telangiectasia needs to be considered as well.

Questions:  Has anyone seen a case?  Any treatment?  Lasers?
References:
1. Cutaneous collagenous vasculopathy with generalized telangiectasia in two female patients.  Perez A, Wain ME, Robson A, Groves RW, Stefanato CM.
Abstract: Cutaneous collagenous vasculopathy is characterized by generalized cutaneous telangiectasia and unique microscopic and ultrastructural vascular changes, consisting of marked collagen deposition within the vascular walls of the post-capillary venules in the superficial dermis. There are only 4 previous cases described in the medical literature, all in males, mostly middle-aged. We have recently seen two female patients with clinical and histopathologic features diagnostic of cutaneous collagenous vasculopathy, indicating that it is not restricted to males. As cutaneous collagenous vasculopathy can be clinically indistinguishable from generalized essential telangiectasia, and histopathologic studies are rarely performed for this condition, it is likely that cutaneous collagenous


2. Generalized essential telangiectasia.
Gordon Spratt EA. Dermatol Online J. 2012 Dec 15;18(12):13.
Abstract: Generalized essential telangiectasia, which is a rare condition that is characterized by the progressive development of telangiectases on the skin, is a clinical diagnosis of exclusion. We present a 65-year-old man with a ten-month history of an asymptomatic eruption of the trunk and proximal aspects of the arms and hands that was comprised of macules and patches of telangiectases. The clinical presentation, associated diseases, hypotheses regarding pathogenesis, differential diagnoses, and reports on treatment modalities are reviewed. The relatively new association of this entity with systemic signs that include hemorrhage as well as the occurrence of generalized essential telangiectasia in patients with a history of hepatitis is discussed.

3.
IMAGES IN CLINICAL MEDICINE. Cutaneous Collagenous Vasculopathy.
Ma DL, Vano-Galvan S. N Engl J Med. 2015 Sep 17;373  Free Full Text.  or DHC.