Tuesday, November 10, 2009

Does this ring a bell?

HPI: The patient is a 36 yo woman on home hemodialysis after a failed renal transplant for membraneous glomerulonephtritis who was referred by her rheumatologist for a "stat" skin biopsy. She sees the rheumatologist for amyloid nephropathy.

Shs is having the second episode of a painful erythematous eruption on the dorsum of the left foot. The first episode, two months ago, resolved after two weeks of Keflex and Bactrim.

Meds: Oxycontin, prednisone 20 mg daily, Keflex (x 4 days)

O/E: This is an upbeat but chronically ill woman. The pertinent findings are on the legs. There is dusky erythema on the dorsum of the left foot. In addition, there are petechaie on both lower extremities. She has a 2/6 pansystolic murmur which the rheumatologist feels is cardiac but her nephrologist feels radiates from her dialysis shunt (left arm).

Clinical Photos:

Labs: CBC: WBC 8900 normal differential. Creatinine 11.32 (normal < 1.2 mg%")
Biopsy: Performed today

: Second episode of an erythematous process left foot. Although this was treated initially as "cellulitis" no real evidence of infection. This does not look infectious to me. I wonder about an embolic phenomenon. I know I have not seen this before.

What is your presumptive diagnosis?
What more would you do at this time?
(On thinking about this patient, and the recurrence, the question of Fixed Drug Eruption arose. I will question her about intermittent prescription and OTC drug use.)

I will give F/U re: bx findings.


  1. Tough case. Thought of purpura, ecchymosis, cellulitis, emboli, cellulitis, contact, stasis derm, hard to tell from pic. DW Johnson, Honolulu

  2. Dr. Merlina Joseph, St.LuciaNovember 10, 2009

    Purpura? Fixed Drug Eruption? Thrombosis? Artifactual Purpura?

  3. Fixed drug is the most likely clinically. A skin biopsy might well help.

  4. I would like to know
    1.Is there any relation with the enviornmental temperature?
    2.Are there any signs or symptoms related to metatarso-phalyngeal joints?

  5. I think it is FDE
    khalifa sharquie

  6. Dr Salman Ch.November 21, 2009

    i think most likely it would be fixed drug eruption.

  7. Agree Fixed Drug - please report if dx achieved?


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