tag:blogger.com,1999:blog-9870114.post111127777746544834..comments2024-03-10T08:41:32.400+00:00Comments on VIRTUAL GRAND ROUNDS IN DERMATOLOGY 2.0: Newborn with VaricellaHumane Medicine Huihttp://www.blogger.com/profile/07113291188306363130noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-9870114.post-1111400740368139222005-03-21T10:25:00.000+00:002005-03-21T10:25:00.000+00:00Jayakar Thomas said...
Thanks Brian for your comm...Jayakar Thomas said...<br /><br />Thanks Brian for your comments.<br />As you rightly pointed out the administration of VZIG for this baby is the right thing but was not economically feasible.<br />I have a doubt. Should this child receive VZV vaccine at age one? Has not the immunity developed with the infection? Can the vaccination be deferred?Humane Medicine Huihttps://www.blogger.com/profile/07113291188306363130noreply@blogger.comtag:blogger.com,1999:blog-9870114.post-1111365523598020322005-03-21T00:38:00.000+00:002005-03-21T00:38:00.000+00:00Comments of Brian Maurer
Pediatric Physician's Ass...Comments of Brian Maurer<br />Pediatric Physician's Assistant<br />Enfield, Connecticut, USA<br /><br />Infants born to mothers who develop varicella infection 5 days before to 2<br />days after delivery are at high risk for developing neonatal varicella<br />infection, which can be severe and sometimes fatal.<br /><br />In the USA, the standing recommendation is to administer Varicella-Zoster<br />Immunoglobulin (VZIG) to these babies, which provides passive protection<br />against VZV for the subsequent 28 days (well beyond the 14 to 21-day<br />incubation period).<br /><br />I don't know about the availability of VZIG in Chennai, or whether the<br />mother was seen by a physician in a timely fashion. VZIG may<br />be impossible to get, or at best very expensive. Still, had this infant<br />gotten VZIG, chances she wouldn't have had to undergo a<br />subsequent 7 to 10-day course of acyclovir at 21 days of age.<br /><br />Congenital varicella syndrome is generally only seen in babies that have<br />been exposed to VZV in utero prior to 20-weeks gestation. Interestingly, if<br />the mother develops varicella more than five days prior to delivery, the<br />infant has less of a chance of developing severe varicella in the neonatal<br />period, due to passive protection afforded by the placental transfer of<br />maternal VZV antibody.<br /><br />Finally, these children should generally receive varicella vaccine at one<br />year of age to boost their immunity to VZV.Humane Medicine Huihttps://www.blogger.com/profile/07113291188306363130noreply@blogger.com